The film is set in 1882, in the Arizona Territory. MacFarlane plays Albert Stark, a sheep farmer who's struggling to find his place in the harsh and unforgiving world of the Wild West. His life takes a turn when he meets Anna (Charlize Theron), a beautiful and strong-willed woman who's also trying to make a new life for herself. As Albert and Anna grow closer, they must navigate a series of hilarious misadventures, including run-ins with a group of eccentric outlaws, a rivalry with a ruthless mining tycoon (Liam Neeson), and a healthy dose of banter with a charming but awkward doctor (Neil Patrick Harris).

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The film is available to stream on various platforms, including Amazon Prime Video, Google Play, and iTunes.

Overall, "A Million Ways to Die in the West" is a hilarious and action-packed Western comedy that's sure to delight fans of Seth MacFarlane and the genre. With its talented cast, clever script, and general absurdity, it's a must-see for anyone looking for a fun and entertaining film.