Use an open-source converter like OpenBabel (free, command-line based) to translate the file into a modern format, then open it in one of the tools above.
The software served its purpose admirably in the early 2000s, but chemistry software has evolved. The modern free tools listed above are safer, more powerful, and actually supported. Isis Draw 2.4 Free Download
Isis Draw 2.4 Free Download: What You Need to Know Before You Click Isis Draw 2.4 Free Download